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Jiangsu Quality Horizons

Our Spirit: Responsibility, Efficiency, Team work, Creativity;
Our Mission: Devoted to the manufacturing of anthelmintics and to be the industrial leader;
Our Vision: To be a guardian of health;
Our Value: Responsible for the customer, Responsible for the staff,Responsible for the society, Responsible for the shareholders.

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■　APIs For Human Use

■　APIs For Veterinary Use

■　Pharmaceutical Intermediates

■　New Products

Closantel Sodium

Synonyms	* Sodium N-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-o-tolyl)-2-hydroxy-3,5-diiodobenzamidate, * EINECS 262-794-7
Chemical Name	Sodium N-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-o-tolyl)-2-hydroxy-3,5-diiodobenzamidate
Molecular formula	C₂₃H₁₅Cl₂I₂N₂NaO₄
Molecular weight	731.080
CAS No.	61438-64-0
Structural formula
Specification	EP / CP(V)
Pharmacodynamic Properties	Closantel is a broad-spectrum antiparasitic agent used against several species and developmental stages of trematodes, nematodes and arthropods. The anti-trematode activity of closantel is mainly used against liver fluke. The anti-nematode and anti-arthropod activity is especially used against those species which feed on blood or plasma. Closantel is an uncoupler of the mitochondrial oxidative phosphorylation resulting in inhibition of the ATP-synthesis. This induces a dramatic change in the energy metabolism which finally leads to the death of the parasite. The drug is widely used in sheep and cattle and can be used either parenterally (s.c. or i.m.) or orally for both prophylactic and therapeutic purposes and is available as drench, bolus and injectable formulations. Closantel has also been combined with mebendazole and several other benzimidazoles in drench formulations for sheep and with levamisole in a bolus for cattle.
Storage	Keep container tightly closed in a cool, well-ventilated area.
MSDS	Please refer to MSDS of Closantel.

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