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Rafoxanide

Synonyms	* Rafoxanidum [INN-Latin], * Rafoxanida [INN-Spanish], * Ranide, * 3'-Chlor-4'-(4-chlorphenoxy)-3,5-diiodsalicylanilid, * 3'-Chloro-4'-(p-chlorophenoxy)-3, 5-diiodosalicylanilide, * AI3-29020, * AIDS-129585, * AIDS129585, * BAS 00336885, * Benzamide, N-(3-chloro-4-(4-chlorophenoxy)phenyl)-2-hydroxy-3,5-diiodo-, * Benzamide, N-[3-chloro-4- (4-chlorophenoxy)phenyl]-2-hydroxy-3, 5-diiodo-, * Benzamide, {N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,} 5-diiodo-, * Bovanide, * BRN 2228187, * Disalan, * Duofas, * EINECS 245-148-9, * Flukanide, * MK-990, * N-(3-Chloro-4-(4-chlorophenoxy)phenyl)-2-hydroxy-3,5-diiodobenzamide, * N-[3-Chloro-4-(4-chloro-phenoxy)-phenyl]-2-hydroxy-3,5-diiodo-benzamide, * NSC 355278, * NSC355278, * RAFOXANIDE, * Rafoxanide [USAN:BAN:INN], * Ranide, veterinary, * Salicylanilide, 3'-chloro-4'- (p-chlorophenoxy)-3,5-diiodo-, * Salicylanilide, 3'-chloro-4'-(p-chlorophenoxy)-3,5-diiodo-,
Chemical Name	N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodo-benzamide
Molecular formula	C₁₉H₁₁Cl₂I₂NO₃
Molecular weight	626.01
CAS No.	22662-39-1
Structural formula
Specification	BPV/CPV
Pharmacodynamic Properties	Rafoxanide is a halogenated salicylanilide. It is an uncoupler of the mitochondrial oxidative phosphorylation resulting in inhibition of the ATP-synthesis. This induces a dramatic change in the energy metabolism which finally leads to the death of the parasite. It binds more strongly to blood proteins, and therefore remain in the blood for longer periods. Rafoxanide is active mainly against adult stages of liver flukes in cattle, sheep, goats and horses. It has lower efficacy against immature flukes may be due to the high protein binding of the drug in the blood. But it has high activity against 6-wk-old flukes in cattle and sheep, by affecting them either at the time of administration or, more probably, by persisting in blood until the flukes start to ingest blood and become exposed to higher drug concentrations. It is also active against gastrointestinal nematodes (Haemonchus, Bunostomum, Oesophagostomum and Gaigeria species) and against the sheep nasal bot fly (Oestrus ovis).
Storage	Keep container tightly closed in a cool, well-ventilated area.
MSDS	Provide as per request after the order or contract is signed.

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